Los Angeles medical examiner says Matthew Perry’s death caused by ‘acute effects of ketamine’
Matthew Perry Actor/Executive Producer Matthew Perry speaks onstage during 'The Odd Couple' panel as part of the CBS/Showtime 2015 Winter Television Critics Association press tour at the Langham Huntington Hotel & Spa on January 12, 2015 in Pasadena, California. (Frederick M. Brown/Getty Images)
By Jessica Goodman, Cox Media Group National Content Desk
LOS ANGELES — “Friends” star Matthew Perry’s cause of death was “acute effects of ketamine,” the Los Angeles County Medical Examiner said.
The autopsy report was released Friday nearly two months after Perry was found unresponsive in a hot tub at his house on Oct. 28, according to The New York Times. He was 54.
The medical examiner said that contributing factors to Perry’s death were drowning, coronary artery disease and the effects of buprenorphine, according to online records. Buprenorphine is used to treat opioid use disorder.
The report said that Perry was found by his live-in assistant face down in the pool after he got back home from running errands, according to The Associated Press. The assistant reportedly told investigators that Perry was not sick, did not show any signs of any recent drug or alcohol use, and had not complained about feeling ill.
The autopsy said that Perry was going through “ketamine infusion therapy.” His most recent therapy was more than a week before he died. The report notes that the therapy could not have been the cause of his death due to the high levels of ketamine found in his blood. Ketamine metabolizes out of the body within hours.
Ketamine is “is a powerful anesthetic that has become increasingly popular as an alternative therapy for depression, anxiety, post-traumatic stress disorder and other hard-to-treat mental health problems,” according to the Times.
The Food and Drug Administration issued an alert in October about how dangerous it could be to treat psychiatric disorders with “compounded versions of the drugs,” the Times reported.
Perry, known for his role as Chandler Bing on the sitcom “Friends” from 1994 to 2004, was open about his struggles with addiction dating back to when he starred on the television series, the AP reported.
“We are all so utterly devastated by the loss of Matthew. We were more than just cast mates. We are a family. There is so much to say, but right now we’re going to take a moment to grieve and process this unfathomable loss,” Perry’s “Friends” cast members Jennifer Aniston, Courteney Cox, Lisa Kudrow, Matt LeBlanc and David Schwimmer wrote in a statement after his death, according to Variety. “In time we will say more, as and when we are able. For now, our thoughts and our love are with Matty’s family, his friends, and everyone who loved him around the world.”
Photos: Matthew Perry through the years 1994: Matthew Perry as Chandler Bing on "Friends" in 1994. (Reisig & Taylor/NBCU Photo Bank/NBCUniversal via Getty Images)
Photos: Matthew Perry through the years 1995: Matt LeBlanc, Jennifer Aniston, Matthew Perry, Lisa Kudrow, Courtney Cox and David Schwimmer of the TV show "Friends" attend the 21st annual People's Choice Awards on March 5, 1995, at the Universal Studios in Universal City, California. (Ron Davis/Getty Images)
Photos: Matthew Perry through the years 1997: "Friends" co-stars actress Lisa Kudrow and actor Matthew Perry attend the 49th annual Primetime Emmy Awards on September 14, 1997, at the Pasadena Civic Auditorium in Pasadena, California. (Ron Davis/Getty Images)
Photos: Matthew Perry through the years 1999: Actress Jennifer Aniston, actress Courteney Cox, actor Matt LeBlanc, actress Lisa Kudrow, actor Matthew Perry and actor David Schwimmer attend the fifth annual Screen Actors Guild Awards on March 7, 1999, at the Shrine Auditorium in Los Angeles. (Ron Galella, Ltd./Ron Galella Collection via Getty Images)
Photos: Matthew Perry through the years 2001: Left, Matthew Perry, Matt LeBlanc and David Schwimmer arrive at the 28th annual People's Choice Awards held at the Pasadena Civic Auditorium in Los Angeles on Jan. 13, 2001. (Kevin Winter/Getty Images)
Photos: Matthew Perry through the years 2002: Actors David Schwimmer, Lisa Kudrow, Matthew Perry, Courteney Cox Arquette, Jennifer Aniston and Matt LeBlanc pose backstage during the 54th annual Primetime Emmy Awards at the Shrine Auditorium on September 22, 2002, in Los Angeles. Aniston won Outstanding Lead Actress in a Comedy Series for "Friends." (Robert Mora/Getty Images)
Photos: Matthew Perry through the years 2003: Actor Matt LeBlanc, actress Lisa Kudrow and actor Matthew Perry pose during the ninth annual Screen Actors Guild Awards at the Shrine Auditorium on March 9, 2003, in Los Angeles. (Kevin Winter/Getty Images)
Photos: Matthew Perry through the years 2004: Actors Bruce Willis (left) and Matthew Perry talk at the after-party for the premiere of Warner Bros. "The Whole Ten Yards" at the Sunset Room on April 7, 2004, in Los Angeles. (Kevin Winter/Getty Images)
Photos: Matthew Perry through the years 2005: Actor Matthew Perry (left) and actress Courteney Cox arrive at the series premiere for TBS' "Daisy Does America" at Guy's on November 29, 2005, in Los Angeles. (Michael Buckner/Getty Images)
Photos: Matthew Perry through the years 2006: Actor Matthew Perry and actress Courteney Cox Arquette mingle at the AFI Associates luncheon honoring Hollywood's Arquette family with the 6th annual "Platinum Circle Award" held at the Regent Beverly Wilshire Hotel on May 10, 2006, in Beverly Hills, California. (Kevin Winter/Getty Images for AFI)
Photos: Matthew Perry through the years 2007: Actors Lisa Kudrow and Matthew Perry picket in support of the Writers Guild of America which is currently on-strike for increased residuals from film and television profits in front of the Universal Studios Lot November 13, 2007, in Universal City, California. (Matthew Simmons/Getty Images)
Photos: Matthew Perry through the years 2008: Actor Matthew Perry leaves the Dolce's Five Year Anniversary at the Dolce Enoteca on May 20, 2008, in Los Angeles. (Valerie Macon/Getty Images)
Photos: Matthew Perry through the years 2009: Actors Michelle Trachtenberg, Zac Efron, Leslie Mann and Matthew Perry arrive at the premiere of Warner Bros. "17 Again" held at Grauman's Chinese Theatre on April 14, 2009, in Hollywood, California. (Kevin Winter/Getty Images)
Photos: Matthew Perry through the years 2010: Actors Matthew Perry (left) and Lauren Graham present the Guest Actress & Actor in a Comedy Series awards onstage at the 62nd annual Primetime Emmy Awards held at the Nokia Theatre L.A. Live on August 29, 2010, in Los Angeles. (Kevin Winter/Getty Images)
Photos: Matthew Perry through the years 2011: Actor Matthew Perry and co-founder/editor-in-chief of The Huffington Post Arianna Huffington arrives at the Arianna Huffington & The Huffington Post presents Bill Maher and The Best of Huffpost Comedy event at The Roxy Theater on February 23, 2011, in West Hollywood, California. (Angela Weiss/Getty Images)
Photos: Matthew Perry through the years 2012: Actress Matthew Perry arrives at the 64th annual Primetime Emmy Awards at Nokia Theatre L.A. Live on September 23, 2012, in Los Angeles. (Frazer Harrison/Getty Images)
Photos: Matthew Perry through the years 2013: Actor Mathew Perry poses after the 2013 Huading Awards Ceremony at The Venetian on October 7, 2013, in Macau, Macau. (Lam Yik Fei/Getty Images for Global Talents Media Group)
Photos: Matthew Perry through the years 2014: Actors Matthew Perry (left) and Thomas Lennon attend the CBS, The CW, Showtime & CBS Television Distribution's 2014 TCA Summer Press Tour Party at Pacific Design Center on July 17, 2014, in West Hollywood, California. (Imeh Akpanudosen/Getty Images)
Photos: Matthew Perry through the years 2015: Actor Matthew Perry attends Venice Family Clinic's Silver Circle Gala at Regent Beverly Wilshire Hotel on March 9, 2015, in Beverly Hills, California. (Mike Windle/Getty Images for Venice Family Clinic)
Photos: Matthew Perry through the years 2016: Actors Thomas Lennon (left), Wendell Pierce, Yvette Nicole Brown, Lindsay Sloane and Matthew Perry attend the CBS, CW, Showtime Summer TCA Party at Pacific Design Center on August 10, 2016, in West Hollywood, California. (Matt Winkelmeyer/Getty Images)
Photos: Matthew Perry through the years 2017: Actors Katie Holmes (left) and Matthew Perry at the premiere of Reelz's "The Kennedys After Camelot" at The Paley Center for Media on March 15, 2017, in Beverly Hills, California. (Frazer Harrison/Getty Images)
Photos: Matthew Perry through the years 2022: Matthew Perry looks on during the Women’s Singles Final match between Iga Swiatek of Poland and Ons Jabeur of Tunisia on Day Thirteen of the 2022 US Open at USTA Billie Jean King National Tennis Center on September 10, 2022, in the Flushing neighborhood of the Queens borough of New York City. (Elsa/Getty Images)